External Apical Root Resorption and IL-1A, IL-1RN Gene Polymorphisms: A Systematic Review and Meta-Analysis of Prospective Studies

ABSTRACT Objective: To reconnoiter the IL-1A (-889) and IL-1RN (+2018) gene polymorphisms and their association with EARR. Material and Methods: The Science Direct, PubMed and Scopus databases were comprehensively searched by two independent reviewers. In addition, the bibliographies of all relevant publications and textbooks were searched manually. A meta-analysis was performed using data available up to May 9, 2020. Results: A total of 13 and 9 publications were selected for the systematic review and meta-analysis, respectively for both IL-1A and IL-1RN genes. Odds ratio (OR) was used to evaluate the association of the gene polymorphism and the risk of EARR. The risk of EARR was estimated using the overall OR from the published studies. No association was found for IL-1A gene for the risk of EARR. However, the dominant and co-dominant models of IL-1RN gene polymorphism were associated with the risk of EARR. Conclusion: More studies are warranted to determine the relationship between IL-1A and IL-1RN gene polymorphisms and EARR for a clearer understanding of their interactions.

Pain Perception and Rate of Canine Retraction Through Self-Ligating Brackets and Conventional Elastomeric Ligation System: A Split Mouth Study

Abstract Objective: To evaluate the rate of tooth movement and the pain perception via self-ligating (SL) and conventional elastomeric ligation brackets (CB) system. Material and Methods: This study has been conducted at the Orthodontic Department of Baqai Dental College, Baqai Medical University. The sample size of this study comprised 40 patients, falling between the age of 12-30 years without any sex discrimination. Shapiro-Wilk was used to check the distribution of data. Non-parametric Mann Whitney U test was applied to evaluate the pain associated with SL and CB brackets system. To analysis the canine retraction Wilcoxon test was applied for the comparison of CB and SL brackets system. For all statistical analyses, the p-value of <0.05 was considered significant. Results: Pain level associated with retraction via CB and SL shows significant differences. However, the rate of canine retraction via CB and SL shows no significant differences at stages T0-T1 and T1-T2. However, stage T2-T3 shows a significant difference. Conclusion: As pain during orthodontic treatment is mostly associated with the level of compression of the periodontal ligament, it may be hypothesized that lower frictional forces generate less compression of the periodontal ligament and blood vessels, and so alter the type of pain experienced.

Orthodontic Treatment Combination with Auto Transplantation for the Management of Impacted Maxillary Left Lateral Incisor and Canine: An Interdisciplinary Approach.

Aims: For the orthodontic treatment of the complex cases, the interdisciplinary team work is of utmost importance, which leads to the predictable outcome with excellent treatment. The prime aim of this rare case report is to demonstrate the combined orthodontic-surgical-endodonticprosthodontic interdisciplinary management. Presentation of Case: This report describes the case of a 19 years old Malay male patient with the clinical problems of median diastema, mesio-buccally rotated maxillary left 1st premolar, mild mandibular incisor crowding along with impacted maxillary left lateral incisor and canine. Discussion: With the advantages of the orthodontic fixed appliance, auto-transplantation of maxillary upper left lateral incisor and canine, the case was completed in an ideal orthodontic occlusion along with improved oral condition, masticatory function and esthetics. The treatment outcomes were due to orthodontic-surgical-endodontic-prosthodontic treatment with stable occlusion in sequels visits. Conclusion: An Interdisciplinary management achieved successful functional and esthetic results in the present case.